Levodopa is almost completely (~98%) absorbed in the distal part of the duodenum and the proximal jejunum. In advanced Parkinson’s disease (PD), transit of L-dopa from the stomach to the duodenum is erratic with delayed gastric emptying time,leading to fluctuations. By administering L-dopa directly into the proximal small intestine, the influence of gastric emptying rate can be negated…
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