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Motor Fluctuations

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morning akinesia

Apomorphine Subcutaneous Injection for the Management of Morning Akinesia in Parkinson’s Disease

By Stuart Isaacson MD,*, Mark Lew MD, William Ondo MD, Jean Hubble MD, Thomas Clinch BS and Fernando Pagan MD

ABSTRACT Background In patients with motor fluctuations complicating Parkinson’s disease (PD), delays in time-to-ON with levodopa are common. This open-label study aimed to assess the effect of apomorphine on time-to-ON in PD patients with morning akinesia. Methods The safety population included 127 enrolled patients, and the full analysis set (FAS) included 88 patients. Patients completed…

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Movement DisordersMovement Disorders is the leading journal on Parkinson’s disease, neurodegenerative & neurodevelopmental disorders & abnormalities in motor control.

Edited By:
Jose A. Obeso, MD, PhD

Movement Disorders Clinical PracticeMovement Disorders Clinical Practice is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders.

Edited By:
Kailash Bhatia, MD, DM, FRCP
Marcelo Merello, MD, PhD

Official journals of the

International Parkinson and Movement Disorder Society

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was made possible by Cynapsus.
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